Synthetic Bone graft: Macroporous Resorbable Biphasic Calcium Phosphate

    MBCP+™ Synthetic bone graft, a 3D interconnected scaffold, mimics the trabecular architecture and the thin cristallin structure of natural bone. Its unique production process, gives an optimal permeability for cells spreading and angiogenesis.
    MBCP+™ is a 100%, cost-effective synthetic bone graft matrix (20% HA, 80% TCP) used as an alternative to biologic osteoinductive products (autograft, allograft).

    MBCP™ Technology’s Key Features


    Provides a matrix for new bone growth

    Molecular mixture of HA and TCP

    HA alone resorbs too slowly while TCP resorbs too fast. Bi-phasic HA and TCP allow for a resorption rate similar to that of human bone.

    70% porosity, similar to cancellous bone

    Interconnected network of macropores and micropores that enables the colonization of bone cells and biological fluid uniformly within the matrix.


    For ionic exchange: TCP dissolution and bone crystal precipitation. Newly bioactive interface with bone cells.


    Macropores are a network of interconnected spaces that promote the biological infiltration and cellular colonization by osteoblasts and osteoclasts.


    Micropores are the intercrystalline spaces where dissolution and recrystallisation occurs.

    >30 years of clinical experience

    Host bone formation is systematically demonstrated.


    100% synthetic – 5 years shelf life.

    1. Daculsi G, Laboux O, Malard O, Weiss P. Current state of the art of biphasic calcium phosphate bioceramics. J Mater Sci Mater Med. (2003) Mar;14(3):195-200 -More-
    2. Daculsi G., LeGeros R. Z, Grimandi G., Soueidan A., Aguado E., Goyenvalle E., LeGeros J., Effect of Sintering Process of HA/TCP Bioceramics on Microstructure, Dissolution, Cell Proliferation and Bone Ingrowth, Key Engineering materials Vols 361-363 (2008) pp1139-1142 -More-
    3. Changseong K., Sung Cho K., Daculsi C., Seris E. , Daculsi G., Eight-Year Clinical Follow-Up of Sinus Grafts with Micro-Macroporous Biphasic Calcium Phosphate Granules, Key Engineering Materials Vol. 587 (2014) pp 321-324 -More-
    4. Rodriguez C., Jean A., Daculsi G., Five Years Clinical Follow up Bone Regeneration with CaP Bioceramics, Key Engineering Materials Vols. 361-363 (2008) pp. 1339-1342 -More-
    5. Daculsi G., Jegoux F. and Layrolle P., The micro macroporous biphasic calcium phosphate concept for bone reconstruction and tissue engineering. in Advanced Biomaterials: Fundamentals, Processing, and Applications book, Basu B. et al., Wiley J. and sons Inc., (2009) pp 101-141 -More-
    6. Fellah B., Gauthier O., Weiss P., Chappard, D. Layrolle P., Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat model, Biomaterials 29 (2008) 1177-1188 -More-
    7. Lee JH, Jung UW, Kim CS, Choi SH, Cho KS., Histologic and clinical evaluation for maxillary sinus augmentation using macroporous biphasic calcium phosphate in human, Clin Oral Implants Res. (2008) Aug;19(8):767-71. -More-
    8. Daculsi G., Layrolle P., Osteoinductive properties of Micro Macroporous biphasic calcium phosphate bioceramics., Key Engineering Materials (2004);254- 256:1005-8. -More-

    MBCP+™ is intended only for bony voids or gaps that are not intrinsic to the stability of the bony structure. Maximum contact between the product and the recipient bone must be established. Do not overfill defects. A good immobilization of the MBCP+™ ceramic is necessary in order to prevent micromovements which could lead to fibrous encapsulation. Do not leave defect open (e.g. mucosa well sutured and/or use of appropriate membrane). The device should be secured to prevent motion and migration, use in areas where the graft can be adequately contained. Do not compromise blood supply to the defect area. In order to avoid destruction of the porous structure, do not compact granules during delivery into the bony gap. This product is to be handled or implanted by trained qualified persons having read this instruction for use.
    Caution: Federal law in USA and Canada restricts this device to sale by or on the order of a physician or a dentist.

    • ISO 13485
    • Read the instructions for use
    • MBCP+™ is supplied sterile and CE-marked as a Class III Medical Device according to Directive EEC/93/42

    CE 0123

    Certain products may not be approved for sale in all countries.



    • Sinus Lift Augmentation
    • Ridge augmentation
    • Alveolar regeneration
    • Alveolar regeneration


    • Intra-osseous pockets
    • Furcations


    MBCP™ Granules are available in:

    0.25cc – 0.5cc – 1cc
    0.5cc – 2×0.5cc
    2×1.25cc – 1x5cc


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