Combine your cages with our bespoke cage inserts

    Pioneer in Biphasic Calcium Phosphate Solutions, especially in custom inserts for spinal cages, Biomatlante has been the valued partner of major spinal companies worldwide for over 20 years.7

      • Ready to use cage filler1,4,5,7,12,19
      • Operating time saved with prefilled cages1,4,5,7,12,19
      • Cost effective and safe7,12,18,22

    Biomatlante does not manufacture any spinal cages

    MBCP™ Technology’s Key Features

    Osteoconductive1,2,3,16

    Provides a matrix for new bone growth

    Molecular mixture of HA and TCP4,17,18

    HA alone resorbs too slowly while TCP resorbs too fast4,17,18. Bi-phasic HA and TCP allow for a resorption rate similar to that of human bone7,19,21.

    70% porosity, similar to cancellous bone4

    Interconnected network of macropores and micropores that enables the colonization of bone cells and biological fluid uniformly within the matrix.4,8,15,20

    Bioactive1,4,16

    For ionic exchange: TCP dissolution and bone crystal precipitation create a newly bioactive interface with bone cells.

    Macroporosity8,9,10,15,20

    Macropores are a network of interconnected spaces that promote the biological infiltration and cellular colonization by osteoblasts and osteoclasts.

    Microporosity8,9,10,20

    Micropores are the intercrystalline spaces where dissolution and recrystallisation occurs.

    >30 years of clinical experience1,6,11,12

    Host bone formation is demonstrated.

    Safe7,12,13,22

    100% synthetic4,17.

    The effectiveness of MBCP™ has been critically evaluated in a large prospective randomized study involving 341 patients undergoing posterior spinal fusion with associated instrumentation7. The performance of MBCP™ was characterized by:

    • Equivalent clinical outcome to autologous bone graft
    • Fewer spinal wound healing problems than autologous grafts
    • Avoidance of donor site pain and infections
    • No allergic reactions

    [1] Passuti – 1989 – “Macroporous Calcium Phosphate Ceramic Performance in Human Spine Fusion” Clinical Orthopaedics
    [2] Rodriguez – 2008 – “Five Years Clinical follow-up Bone Regeneration with CaP bone ceramics” Key Engineering Materials
    [3] Kolerman – 2012 – “Clinical Radiographic and Histomorphometrical Analysis of Maxillary Sinus Augmentation using Synthetic Bone Substitute” Journal of Oral and Maxillofacial Surgery
    [4] Legeros – 2002 – “Properties of Osteoconductive Biomaterials: Calcium Phosphates” – Clinical Orthopedics
    [5] Cavagna – 1999 – “Macroporous Calcium Phosphate Ceramic : a prospective study of 106 cases in Lumbar Spinal Fusion” Journal of Long-Rerm Effects of Medical Implants
    [6] Rouvillain – 2009 – “Clinical, radiological and histological evaluation of biphasic calcium phosphate bioceramic wedges filling medial high tibial valgisation osteotomies” The Knee
    [7] Ransford – 1998 – “Synthetic porous ceramic compared with autograft in scoliosis surgery 341 patient randomised study” The Journal of Bone and Joint Surgery
    [8] Daculsi – 2008 – “Effect of sintering process of HA/TCP bioceramics on microstructure, dissolution, cell proliferation and Bone ingrowth” Key Engineering Materials
    [9] Miramond – 2014 – “Comparative critical study of commercial calcium phosphate bone substitutes in terms of physico-chemical properties” – Key Engineering Materials
    [10] Duan – 2017 – “Variation of bone forming ability with the physicochemical properties of calcium phosphate bone substitutes” – Article on line
    [11] Xie – 2006 – “Evaluation of the osteogenesis and biodegradation of porous biphasic ceramic in the human spine, 20 patients” Biomaterials
    [12] Pascal–Mousselard – 2006 – “Anterior Cervical Fusion With PEEK Cages: Clinical Results of a Prospective, Comparative, Multicenter and Randomized Study Comparing Iliac Graft and a Macroporous Biphasic Calcium Phosphate” North American Spine Society
    [13] Lavallé – 2004 – “Biphasic Ceramic wedge and plate fixation with locked adjustable screws for open wedge tibial osteotomy” Revue de chirurgie orthopédique
    [14] Gouin – 1996 – “Clinical applications of calcium phosphate ceramics” SOFCOT teaching supplement
    [15] Gauthier – 1998 – “Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth” Biomaterials
    [16] Cho – 2011 – “Bioactivity and osteoconductivity of biphasic calcium phosphates” Bioceramics Development and Applications
    [17] Nery – 1992 – “Tissue response to biphasic calcium phosphate ceramic with different ratios of HA/TCP in periodontal osseous defects” – Journal of Periodontology
    [18] Schaefer – 2011 – “How degradation of calcium phosphate bone substitute materials is influenced by phase composition and porosity” – Advanced Engineering Materials
    [19] Daculsi – 2013 – “Clinical studies of anterior cervical fusion with PEEK cages: comparing illiac graft and a Macroporous Biphasic Calcium Phosphate
    [20] Legeros – 1988 – “Significance of the porosity and physical chemistry of Calcium Phosphate Ceramics Biodegradation-Bioresorption
    [21] Daculsi – 1999 – “Spongious and cortical bone substitution kinetics at the expense of macroporous biphasic calcium phosphate : animal and human evidence” Bioceramics
    [22] Changseong – 2014 – “Eight-Year clinical follow-up of sinus grafts with Micro-Macroporous biphasic calcium phosphate granules” Key Engineering Materials
    [23] Gouin – 1995 – “Biphasic macroporous calcium phosphate ceramine bone substitute for filling bone defects : a report of 23 cases” Revue de Chirurgie Orthopédique

    To read the complete precautions, please refer to the Instructions for Use.
    The product must only be handled or implanted by trained qualified physicians having read the instructions for use.
    MBCP™ is intended for use by surgeons familiar with bone grafting and rigid fixation techniques.

    • ISO 13485
    • Read the instructions for use
    • MBCP™ is supplied sterile and CE-marked as a Class III Medical Device according to Directive EEC/93/42

    Not all products are registered or available in every country/region. Please check with Biomatlante representative for availability and further information.

    Indications

    Spine

    • Interbody Cage Fusion

    Availability

    MBCP™ Inserts (blocks) are available in custom-made shapes for:

    Sterile and non sterile
    Sterile and non sterile

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