Moldable Synthetic Bone Graft Substitute

    Building on Biomatlante’s core MBCP™ Technology, In’Oss™ is an innovative and moldable synthetic bone graft, composed of Hydroxyapatite (HA), Beta Tricalcium Phosphate (ß-TCP) and a hydrogel.
    Developed to facilitate handling during bone grafting procedures, In’Oss™ can fit into different grafting sites.
    In’Oss™, is the optimal balance between MBCP™ micro granules and an absorbable hydrogel, acting as a carrier for rapid vascularization and mineralization.
    In’Oss™ keeps the original graft shape and bone volume. It is gradually absorbed to be replaced by vital architectured bone.

    MBCP™ Technology’s Key Features


    Provides a matrix for new bone growth

    Molecular mixture of HA and TCP

    HA alone resorbs too slowly while TCP resorbs too fast. Bi-phasic HA and TCP allow for a resorption rate similar to that of human bone.

    70% porosity, similar to cancellous bone

    Interconnected network of macropores and micropores that enables the colonization of bone cells and biological fluid uniformly within the matrix.


    For ionic exchange: TCP dissolution and bone crystal precipitation. Newly bioactive interface with bone cells.


    Macropores are a network of interconnected spaces that promote the biological infiltration and cellular colonization by osteoblasts and osteoclasts.


    Micropores are the intercrystalline spaces where dissolution and recrystallisation occurs.

    >30 years of clinical experience

    Host bone formation is systematically demonstrated.


    100% synthetic – 5 years shelf life.

    1. The safety and efficacy of an injectable bone substitute in dental sockets demonstrated in a human clinical trial. Weiss P., Layrolle P., Clergeau LP., Enckel B., Pilet P., Amouriq Y., Daculsi G., Giumelli B., Biomaterials. 2007 Aug;28(22):3295-305.
    2. Maxillary Sinus Bone Grafting with an Injectable Bone Substitute: a Sheep Study, A.Saffarzadeh, O. Gauthier, and al., Key Engineering Materials Vols. 254-256 (2004) p. 193-196
    3. Tricalcium phosphate/hydroxyapatite biphasic calcium phosphate (BCP) bioceramics , in Bioceramics and theirs clinical applications, Daculsi G., LeGeros R., T. Kokubo editor, Woodhead publishing, 2008, pp 395-4242
    4. A New Injectable Bone Substitute Concept (MBCP Gel ™): First Clinical Results in Human Maxillo-Facial Surgery, Pierre Weiss, Léon Philippe Clergeau, Bénédicte Enckel, Yves Amouriq, Bernard Giumelli, Alain Jean and Guy Daculsi, Key Engineering Materials Vols. 284-286 (2005) pp. 1053-1056
    5. Five Years Clinical Follow up Bone Regeneration with CaP Bioceramics Clemencia Rodríguez, Alain Jean, and Guy Daculsi, Key Engineering Materials Vols. 361-363(2008) pp. 1339-1342
    6. Assessment of Cancellous Bone Architecture after Implantation of an Injectable Bone Substitute, Catherine A. Davy, O. Gauthier, and al., Key Engineering Materials Vols. 254-256 (2004) pp. 55-5842

    Do not overfill defects.
    • Do not leave the defect opened
    • In’Oss™ has to be in direct contact with at least 2 or 3 surfaces. Maximum contact between In’Oss™ and recipient bone must be achieved.
    • In’Oss™ does not have initial mechanical properties and should not be used for load-bearing applications without independent rigid fixation or any kind of osteo synthetic stabilisation.
    • Adequate post-operative immobilization is to be used to facilitate the osteogenesis.
    • Post surgery discharge is necessary.
    • Implantation is not recommended in revision surgery site containing non resorbable biomaterials residues.
    • The product has not been tested on pregnant women. The risk of health has not been established.

    • ISO 13485
    • Read the instructions for use
    • MBCP™ is supplied sterile and CE-marked as a Class III Medical Device according to Directive EEC/93/42

    CE 0123

    Certain products may not be approved for sale in all countries.


    Is indicated augment or substitute for bone graft in nonloadbearing clinical applications


    • Posterolateral Fusion


    In’Oss is available in:

    0.5ml – 1ml


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