MBCP™: Synthetic Bone Graft Substitute
Bioactive Calcium Phosphate
Ideally, any biocompatible synthetic bone graft substitute material used to replace or augment graft material should become integrated with the surrounding bone tissue and ultimately be replaced by new healthy bone, as seen with autologous graft7.
MBCP™ is a biphasic calcium phosphate synthetic bone graft substitute with a unique micro and macroporous structure that most closely resembles to the architecture of natural human bone.4 Soluble and resorbable1,2,5,6,16,17,18,21, it gradually dissolves in the body, promoting new bone formation through the release of calcium and phosphate ions. In time, the porous structure becomes completely infiltrated with, and replaced by, healthy viable bone.2,4,8,11
MBCP™ Technology’s Key Features
Provides a matrix for new bone growth
HA alone resorbs too slowly while TCP resorbs too fast4,17,18. Bi-phasic HA and TCP allow for a resorption rate similar to that of human bone7,19,21.
Interconnected network of macropores and micropores that enables the colonization of bone cells and biological fluid uniformly within the matrix.4,8,15,20
For ionic exchange: TCP dissolution and bone crystal precipitation creare newly bioactive interface with bone cells.
Macropores are a network of interconnected spaces that promote the biological infiltration and cellular colonization by osteoblasts and osteoclasts.
Micropores are the intercrystalline spaces where dissolution and recrystallisation occurs.
Host bone formation is demonstrated.
100% synthetic4,17 – 5 years shelf life.
 Rodriguez – 2008 – “Five Years Clinical follow-up Bone Regeneration with CaP bone ceramics” Key Engineering Materials
 Kolerman – 2012 – “Clinical Radiographic and Histomorphometrical Analysis of Maxillary Sinus Augmentation using Synthetic Bone Substitute” Journal of Oral and Maxillofacial Surgery
 Legeros – 2002 – “Properties of Osteoconductive Biomaterials: Calcium Phosphates” – Clinical Orthopedics
 Cavagna – 1999 – “Macroporous Calcium Phosphate Ceramic : a prospective study of 106 cases in Lumbar Spinal Fusion” Journal of Long-Rerm Effects of Medical Implants
 Rouvillain – 2009 – “Clinical, radiological and histological evaluation of biphasic calcium phosphate bioceramic wedges filling medial high tibial valgisation osteotomies” The Knee
 Ransford – 1998 – “Synthetic porous ceramic compared with autograft in scoliosis surgery 341 patient randomised study” The Journal of Bone and Joint Surgery
 Daculsi – 2008 – “Effect of sintering process of HA/TCP bioceramics on microstructure, dissolution, cell proliferation and Bone ingrowth” Key Engineering Materials
 Miramond – 2014 – “Comparative critical study of commercial calcium phosphate bone substitutes in terms of physico-chemical properties” – Key Engineering Materials
 Duan – 2017 – “Variation of bone forming ability with the physicochemical properties of calcium phosphate bone substitutes” – Article on line
 Xie – 2006 – “Evaluation of the osteogenesis and biodegradation of porous biphasic ceramic in the human spine, 20 patients” Biomaterials
 Pascal–Mousselard – 2006 – “Anterior Cervical Fusion With PEEK Cages: Clinical Results of a Prospective, Comparative, Multicenter and Randomized Study Comparing Iliac Graft and a Macroporous Biphasic Calcium Phosphate” North American Spine Society
 Lavallé – 2004 – “Biphasic Ceramic wedge and plate fixation with locked adjustable screws for open wedge tibial osteotomy” Revue de chirurgie orthopédique
 Gouin – 1996 – “Clinical applications of calcium phosphate ceramics” SOFCOT teaching supplement
 Gauthier – 1998 – “Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth” Biomaterials
 Cho – 2011 – “Bioactivity and osteoconductivity of biphasic calcium phosphates” Bioceramics Development and Applications
 Nery – 1992 – “Tissue response to biphasic calcium phosphate ceramic with different ratios of HA/TCP in periodontal osseous defects” – Journal of Periodontology
 Schaefer – 2011 – “How degradation of calcium phosphate bone substitute materials is influenced by phase composition and porosity” – Advanced Engineering Materials
 Daculsi – 2013 – “Clinical studies of anterior cervical fusion with PEEK cages: comparing illiac graft and a Macroporous Biphasic Calcium Phosphate
 Legeros – 1988 – “Significance of the porosity and physical chemistry of Calcium Phosphate Ceramics Biodegradation-Bioresorption
 Daculsi – 1999 – “Spongious and cortical bone substitution kinetics at the expense of macroporous biphasic calcium phosphate : animal and human evidence” Bioceramics
 Changseong – 2014 – “Eight-Year clinical follow-up of sinus grafts with Micro-Macroporous biphasic calcium phosphate granules” Key Engineering Materials
 Gouin – 1995 – “Biphasic macroporous calcium phosphate ceramine bone substitute for filling bone defects : a report of 23 cases” Revue de Chirurgie Orthopédique
The product must only be handled or implanted by trained qualified physicians having read the instructions for use.
MBCP™ is intended for use by surgeons familiar with bone grafting and rigid fixation techniques.
- ISO 13485
- Read the instructions for use
- MBCP™ is supplied sterile and CE-marked as a Class III Medical Device according to Directive EEC/93/42
Orthopaedics and Maxillofacial:
It is intended for use as a bone graft to fill or reconstruct osseous bone defects or gaps of the skeletal system (e.g. extremities, spine and pelvis, dental) that are not intrinsic to the stability of the bone structure. Osseous defects can occur as a result of a trauma or in surgically created defects.
It can be used with autograft as a bone graft extender.
Granules, Sticks, Wedges, Cylinders, Blocks
Custom-made shapes on request