NEWS

Congratulations from Biomatlante team!

Cyril d’Arros, member of Biomatlante’s R&D Department, received the Second Prize for his oral presentation during Bioceramics31 Congress, in New Orleans - USA.

3D moldable scaffold as a new platform for bone tissue engineering strategy with improved handling properties. Cyril d’Arros, Thomas Miramond, Eric Aguado, Pascal Borget, Guy Daculsi

Abstract :

Three kinds of putties for bone regeneration are compared in this study. Two formulations are ready-to-use and one is a powder to be mixed (Freeze Dried Bone Scaffold) with either a physiological solution or with biological agents for a tissue engineering approach. The main differences between the formulations concern the hydroxyapatite/β-tricalcium phosphate ratio of biphasic calcium phosphate (BCP) as mineral filler, the proportion of polymer gel as a carrier, and the method of sterilization. The rheological and handling aspects demonstrate that the new formulation FDBS leads to higher moldability and cohesion properties than the ready-to-use putties, especially with blood or Platelet Rich Plasma (PRP) associations. The biocompatibility and biofunctionality of FDBS are proved by in vivo results (in rabbit femoral epiphysis model with and without osteonecrosis). As a conclusion, FDBS displays essential performances to be considered as a new platform for bone tissue engineering.